张君，博士，助理研究员，一直集中于生物响应型纳米递药体系治疗乳腺癌的研究。设计合成的生物响应型纳米递药体系分别通过诱导肿瘤细胞内铁死亡机制，重塑肿瘤微环境及升高肿瘤细胞内ROS，有效地治疗乳腺癌。在研究过程中注重纳米制剂的安全性及生物响应性，材料选取主要集中在生物可降解、天然无毒和低毒的材料。具备药剂学、化学合成、药理学等相关研究背景，可对生物可降解性材料进行改性研究，制备符合临床需要的相关材料与制剂。发表SCI论文多篇，授权专利1项，主持国家青年基金1项，重庆市自然科学基金1项，8040威尼斯“新进教师启动项目”1项，参与国家自然科学基金（面上项目）1项。

1. Jia Z#, Zhang J#, Wei Y, Pan X, Hu Z, Kang R, Zhou X, Shen Q. Cascade Bioreactors Based on Host–Guest Molecular Inclusion Complexes for Triple-Negative Breast Cancer Therapy via Inducing Ferroptosis. Advanced Functional Materials 2023, 2309727.
2. Deng H#, Zhang J#, Yang Y, Yang J, Wei Y, Ma S, Shen Q. Chemodynamic and Photothermal Combination Therapy Based on Dual-Modified Metal–Organic Framework for Inducing Tumor Ferroptosis/Pyroptosis. ACS Applied Materials & Interfaces 2022, 14(21): 24089-24101.
3. Zhang J#, Yang J#, Zuo T, Ma S, Xokrat N, Hu Z, Wang Z, Xu R, Wei Y, Shen Q. Heparanase-driven sequential released nanoparticles for ferroptosis and tumor microenvironment modulations synergism in breast cancer therapy. Biomaterials 2021, 266: 120429.
4. Zhang J, Zuo T, Yang J, Hu Z, Wang Z, Xu R, Ma S, Wei Y, Shen Q. Hierarchically Releasing Bio-Responsive Nanoparticles for Complete Tumor Microenvironment Modulation via TGF-β Pathway Inhibition and TAF Reduction. ACS Applied Materials & Interfaces 2021, 13(2): 2256-2268.
5. Zhang J, Zuo T, Liang X, Xu Y, Yang Y, Fang T, Li J, Chen D, Shen Q. Fenton-reaction-stimulative nanoparticles decorated with a reactive-oxygen-species (ROS)-responsive molecular switch for ROS amplification and triple negative breast cancer therapy. Journal of Materials Chemistry B 2019, 7(45): 7141-7151.
6. Zhang J, Song J, Liang X, Yin Y, Zuo T, Chen D, Shen Q. Hyaluronic acid-modified cationic nanoparticles overcome enzyme CYP1B1-mediated breast cancer multidrug resistance. Nanomedicine 2019, 14(4): 447-464.
7. Gao X#, Zhang J#, Huang Z, Zuo T, Lu Q, Wu G, Shen Q. Reducing Interstitial Fluid Pressure and Inhibiting Pulmonary Metastasis of Breast Cancer by Gelatin Modified Cationic Lipid Nanoparticles. ACS Applied Materials & Interfaces 2017, 9(35): 29457-29468.
8. Zafar H, Raza F, Ma S, Wei Y, Zhang J*, Shen Q*. Recent progress on nanomedicine-induced ferroptosis for cancer therapy. Biomaterials Science 2021, 9(15): 5092-5115.

发表SCI论文多篇，授权专利1项，主持国家青年基金1项，重庆市自然科学基金1项，8040威尼斯“新进教师启动项目”1项，参与国家自然科学基金（面上项目）1项。